Beilstein J. Org. Chem.2020,16, 1–8, doi:10.3762/bjoc.16.1
hexacarbonylcomplexes; Nicholas reaction; nucleosides; propargyl cation; Introduction
Nucleoside analogs are molecules of high pharmacological interest for the treatment of various conditions, especially cancer and viral diseases [1][2][3][4][5]. The substitution at C-5 of the uracil nucleobase provides a
confirmed that the Nicholas reaction can be carried out in a nucleoside presence, leading to a divergent synthesis of novel metallo-nucleosides enriched with alkene, arene, arylketo, and heterocyclic functions, in the deoxy and ribo series.
Keywords: alkynes; 5-alkynyluridines; C–C-bond formation; dicobalt
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Graphical Abstract
Scheme 1:
Preparation of (2'-deoxy)-5-alkynyluridines 2 and 3, their dicobalt hexacarbonyl derivatives 4 and 5...